The INFUSED project

Drug repositioning for the treatment of myocardial infarction through systems biology approaches

LIH


Articles in journals:

Rodius S, Androsova G, Götz L, Liechti R, Crespo I, Merz S, Nazarov PV, de Klein N, Jeanty C, González-Rosa JM, Muller A, Bernardin F, Niclou SP, Vallar L, Mercader N, Ibberson M, Xenarios I, Azuaje F. Analysis of the dynamic co-expression network of heart regeneration in the zebrafish. Sci Rep. 2016 May 31;6:26822. doi: 10.1038/srep26822.

de Klein N, Ibberson M, Crespo I, Rodius S, Azuaje F. A gene mapping bottleneck in the translational route from zebrafish to human. Front. Genet. 2015; 5:470. doi: 10.3389/fgene.2014.00470.

Rodius S, Nazarov PV, Nepomuceno-Chamorro IA, Jeanty C, Gonzalez-Rosa JM, Ibberson M, da Costa RM, Xenarios I, Mercader N, Azuaje F. Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models. BMC Genomics. 2014; 15:852. doi: 10.1186/1471-2164-15-852.

Azuaje FJ. Selecting biologically informative genes in co-expression networks with a centrality score. Biol Direct. 2014; 9:12. doi: 10.1186/1745-6150-9-12.

Oral and poster presentations at conferences:

(Posters may be found at f1000.com/posters)

Azuaje F, Linking network connectivity information to biologically relevant knowledge. Course "Introduction to Biological Network Analysis", SIB, Lausanne, 15-17 November 2016. (Guest Talk)

Rodius S et al., The integrated analysis of the dynamic transcriptional network of heart regeneration in the zebrafish: Biological insights and connections to mammals. Regulatory Genomics Special Interest Group (RegGenSIG) Meeting, ISMB-ECCB 2015, Dublin, Ireland, 10-14 July, 2015.

Rodius S et al., Systems-Level Identification Of Candidate Hub Genes Controlling Cardiac Regeneration In The Zebrafish, 9th European Zebrafish Meeting, Oslo, 28 June - 2 July, 2015.

Nazarov P, Rodius S, Nepomuceno-Chamorro I et al. Identification of genes with concordant responses in different in vivo models of heart regeneration in zebrafish. In Proc. 9th BeNeLux Bioinformatics Conference, Luxembourg, December 8-9, 2014.

Androsova G, Nazarov P, Rodius S et al. A comprehensive integrative analysis of the transcriptional network underlying the zebrafish heart regeneration. In Proc. 13th European Conference on Computational Biology (ECCB14), Strasbourg, France, 7-10 September, 2014.

De Klein N, Nazarov P, Rodius S et al. Connecting multiple gene expression signatures with candidate drugs for boosting heart regeneration potential. In Proc. 13th European Conference on Computational Biology (ECCB14), Strasbourg, France, 7-10 September, 2014.

Azuaje F, Systems-based insights into the transcriptional dynamics of zebrafish heart regeneration (Guest Talk), Featured Symposium on Systems Biology in Cardiovascular Disease: Putting it all together, Frontiers in CardioVascular Biology 2014, 4 July 2014, Barcelona, Spain.

Wang H, Zheng H, Azuaje F. Improving the detection of biologically meaningful clusters in protein interactions networks through integrated functional analysis. In Proc. of BBC13 (Benelux Bioinformatics Conference 2013), Brussels, 9-10 December 2013.

Rodius S, Nazarov PV, Bernardin F, Jeanty C, Muller A, Niclou SP, Vallar L, Azuaje F. Transcriptional dynamics of heart regeneration in zebrafish. Conference on Zebrafish Models in Translational Medicine, Courcelles-sur-Yvette, France, 2-4 October 2013.

Nazarov PV, Muller A, Rodius S, Jeanty C, Niclou SP, Vallar L, Azuaje F. Dissecting the transcriptional dynamics of zebrafish heart regeneration through network-based approaches. Joint 21st Annual International Conference on Intelligent Systems for Molecular Biology and 12th Annual European Conference on Computational Biology (ISMB/ECCB 2013), Berlin 20 - 22 Jul 2013.

Nazarov PV, Muller A, Rodius S, Jeanty C, Niclou SP, Vallar L, Azuaje F. A systems-based characterization of the transcriptional dynamics of heart regeneration in zebrafish. 8th European Zebrafish Meeting, Barcelona, 9 - 13 Jul 2013.